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Cell 185 , 24522468e16 (2022)

Without that provider statement, the icd 10 code for iron deficiency anemia can't be assigned and D64.9 is the only defensible code

Key pathophysiologic mechanisms include: Mucosal barrier dysfunction: Impaired epithelial tight junctions allow bacterial translocation, triggering innate immune activation T-helper cell dysregulation: Predominantly Th1 and Th17 pathways drive chronic inflammation via TNF-, IL-12, IL-23 the basis for biologic therapy targets Transmural inflammation: Unlike UC (mucosal only), CD involves all layers: mucosa submucosa muscularis propria serosa Granuloma formation: Non-caseating granulomas are pathognomonic but present in only ~3050% of biopsies Fibrosis and stricture: Chronic inflammation activates myofibroblasts collagen deposition luminal narrowing obstructive symptoms Fistula formation: Transmural ulcers penetrate serosa form sinus tracts connect to adjacent bowel, bladder, vagina, or skin 7

Internal Study, Willow, BD, 2018

Ozempic (semaglutide) is a GLP-1 peptide for blood-sugar and weight management

But high blood levels of B12 do not mean symptoms are well treated