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This leads to aggregation of lipid-acylated-related proteins, loss of iron-sulfur cluster proteins, and ultimately, cell death due to intracellular proteotoxic stress (5)

Chen YC, Chen YW, Hsu HS, Tseng LM, Huang PI, Lu KH, et al

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In contrast, FGF23 binds to the KlothoFGFR complex and activates the Mitogen-Activated Protein Kinase/Extracellular signal-Regulated Kinase 1 and 2 pathway, leading to the suppression of CYP27B1 and upregulation of the catabolic enzyme 24-hydroxylase (CYP24A1), which accelerates the degradation of 1,25(OH)D (13)

Serpins promote cancer cell survival and vascular co-option in brain metastasis