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In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Wilson C., Munoz-Palma E., Gonzalez-Billault C

[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Li Y, et al

Al found that GHK-Cu increases the rate of wound healing decreases rejection of transplanted skin grafts, and even has anti-inflammatory properties

Further, it has been proposed that hypoxia-induced suppression of GPx-1 transcription may contribute to reperfusion injury after low oxygen tension in vivo (253)