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Aspartate metabolism facilitates IL-1 production in inflammatory macrophages

For this experiment, activated HL-60 cells were transfected with scramble siRNA (control), FPR1 siRNA or CXCR1 siRNA for 3 days and then the cells were co-incubated with His-tagged N0362 for 2 h

Please forgive me if I take a little segue

Because the in-vitro (cell-culture) literature is large and biochemically interesting, while the human-trial literature is much smaller

The former has a very short lifetime, while the latter, although short-lived, has a longer lifetime than the former

Clinical Considerations Connectivetissue diseases are invaluable clinical models of systemic immunemediated pathology, highlighting how dysregulated immune responses converge on structural connectivetissue components throughout the body