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Dermatology Pract

FIGURE 2 Several important processes in metabolism are found within the mitochondrial matrix, including pyruvate decarboxylation by the pyruvate dehydrogenase complex (PDC), which converts pyruvate to acetyl coenzyme A (acetyl-CoA), and the same holds for fatty acid beta-oxidation enzymes and the production of acetyl-CoA from free fatty acids

Zhu L, Han B, Wang L, Chang Y, Ren W, Gu Y, et al

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J Clin Invest 106 : 483491

Senescent cells can also produce various pro-inflammatory chemokines and cytokines, leading to the accumulation of senescent cells that impair normal tissue function, including tissue dysfunction, limited regeneration, and tumor development 113