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Inhibiting PHGDH or PSAT1 in IDH2-high cells significantly disrupts the TCA cycle by reducing the availability of -KG and other intermediates, thereby impairing mitochondrial respiration and energy production
For example, a plants tolerance to stress can be regulated by both the phenylpropanoid biosynthesis pathway and the plant hormone signal transduction pathway
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doi: 10.3390/compounds3010005 162 ZhangZLiXSangSMcClementsDJChenLLongJet al
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