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A responsible prescriber will screen for all of these in advance, baseline an IGF-1 and fasting glucose panel, and re-test on a defined schedule even though AOD-9604 in trials did not move those markers

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Abdominal pain or discomfort affects 10-15% of users

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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes