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102(37): e34959

This was due to the presence of autoantibodies against folate receptor which blocked the folate binding site

Organ-specific toxicity is another critical area of concern

Furthermore, structural modifications within the CNS are facilitated by central disinhibition, as demonstrated by the transformation of A nerve fibers, which typically transmit non-painful stimuli, into pain-specific secondary neurons in the dorsal horn of the spinal cord [42]

The pain usually affects the lower extremities first and extends upward through hosiery-like sensory abnormalities [81, 82]

doi:10.4067/s0034-98872017000700907