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-Synuclein (-Syn) binds Cu 2+ with high affinity via its N-terminal amine, the side chain of Asp2, and the imidazole group of His50, inducing conformational changes that modulate copper redox activity, reduce oxidative stress, and promote membrane recycling and SNARE-complex membrane fusion (172)

199 In bladder cancer, METTL3 is significantly overexpressed in patient-derived samples and facilitates the advancement of bladder cancer through the AFF4/NF-B/MYC signaling cascade

10.1007/s00709-013-0528-5 50 DinlerB

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Severely affected patients present in the first few days of life with non-ketotic hypoglycemia, hyperammonemia, and metabolic acidosis accompanied by hypotonia, encephalopathy, hepatomegaly, cardiomyopathy, and poor prognosis

In organ transplantation, trained immunity has been shown to modulate the fate of grafts, as demonstrated in animal models