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Clinical Update 4/14/2013 Concern Over Carnitine Causing Cardiovascular Disease Intake of L-carnitine from supplements (and from red meat) may foster atherosclerosis (hardening of the arteries), according to new research

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Porphyromonas gingivalis regulates atherosclerosis through an immune pathway

Humans maintain carnitine homeostasis through dietary intake and endogenous synthesis, with estimated daily requirements of 0.31.9 mg/kg/day (11)

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Specifically, the % change of in the L-C intervention arm was 9.3% (p = 0.02) greater than in the placebo arm, which corresponded to an absolute between arm difference of 2.7% ( p = 0.03)