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As Jadad scoring relates purely to risk of bias, other variables affecting study quality such as presence of placebo arm, population size, power and duration of follow-up are addressed in text

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97.Oh-I S, Shimizu H, Satoh T, et al

After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity [21]) and reaching pre-arrival body weights (~38g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation

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