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Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13

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Supplementation with exogenous DAO has recently been postulated as a complementary treatment to enhance dietary histamine degradation in intolerant individuals who have a deficiency of this enzyme in the intestine [109,110]