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Aberrant DNA and histone methylation patterns are a hallmark of cancer [193,194,195] and many genetic and epigenetic functional studies have identified methyltransferases to be frequently mutated in all types of malignancies [196,197,198,199,200,201]

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201 Particularly, FTO gene polymorphism rs9939609 and rs9940128 are closely associated with hyperglycemia, insulin resistance and diabetes mellitus in different populations