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A more recent study described the subgingival microbial profile of children and adolescents with cleft and suggested higher relative proportion of Gram-negative anaerobic bacteria in teeth near the cleft compared with the control group (67)

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furthermore, could down-regulate release of proinflammatory Th1 cytokines (i.e., TNF- and IFN-) and stimulate macrophages to generate anti-inflammatory cytokines to minimize the risk of ARDS in COVID-19 691

This discrepancy suggests that the conventional view that LCACs are generally harmful may not be universally applicable to all types of LCACs

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Not suitable for children under 15 years or for pregnant or lactating women