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Specific dietary components, including refined sugars, saturated fats and additives, compromise epithelial TJs, increase intestinal permeability and trigger inflammation.26 This diet-dependent immune modulation milieu involves another significant player, the gut microbiome, which completes the paradigm of the intestinal barrier-diet-microbiome triangle

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Gradually increasing within standard ranges may help

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2 Neurodegenerative disorders 2.1 Alzheimer's disease (AD) Evidence indicates that gut microbiota composition is altered in AD, with a trend toward reduced diversity and specific bacterial taxa linked to disease severity

Section specific changes in permeability were also measured ex vivo by Ussing chambers which demonstrated that the ileum had the most dynamic changes