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Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

Obese Zucker rats treated with AOD-9604 at 500 mcg/kg/day for 19 days showed a statistically significant reduction in body fat compared to vehicle-treated controls

In rodent models, blocking NNMT with 5-Amino-1MQ led to lower fat mass, more energy burn, and better insulin response all without cutting calories

As such, AOD-9604 may be best viewed as a supportive tool within a comprehensive metabolic plan, not a standalone weight loss solution

Current approaches include: Continuous Use Approach: Based on clinical trials that used continuous daily administration for 12-24 weeks without scheduled breaks

One study suggests that you absorb three per cent at doses of 50 micrograms (thats just 1.5 micrograms) but only 1.3 per cent at doses of 1,000 micrograms (13 micrograms)