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Notably, experiments in mice showed that a high-fat diet or clock-disrupting conditions alter microbial rhythms, which then contributes to hepatic circadian clock dysfunction and obesity

doi: 10.1098/rsob.200291 19 SchweigerMSchreiberRHaemmerleGLassAFledeliusCJacobsenPet al

doi: 10.3389/fbioe.2021.628569 94 RoD

After treatment with 0.5 g/ml of STW3-VI or 1.0 M desipramine hydrochloride (Sigma-Aldrich) the differentiation and neurites growth was followed and photographs were taken at 0, 24, and 48 h, using an inverted microscope (Zeiss Axiovert 135) equipped with a XY motorized stage and AxioVision 4 Modul Mark & Find 2 (Carl Zeiss GmbH)

However, this dosing is from animal studies and has not been validated for human use