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B vitamins, especially B2 (riboflavin) and B3 (niacin), are essential cofactors for mitochondrial energy pathways

Philos Trans R Soc Lond B Biol Sci 268: 5566, 1974

Moreover, mitochondrial damage elevates ROS levels (380), which can in turn damage mtDNA and proteins that may be involved in the electron transport chain (ETC), resulting in lowered ATP production and decreased energy levels (381)

Therefore, more researches are still necessary to reveal the roles and action mechanisms of NNMT in obesity and T2D and to develop therapeutics targeting NNMT

Common Symptoms of Retinol Deficiency: The most visible signs of vitamin A deficiency can be seen by examining the eyes and skin

Again, all doses should be personalised and monitored by a qualified clinician