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Age-related NAD+ decline impairs this critical DNA repair pathway CD38 balance: The ectoenzyme CD38 consumes NAD+ and increases with age, creating a vicious cycle of NAD+ depletion and immune dysregulation By restoring NAD+ levels, supplementation recalibrates multiple aging pathways simultaneously: improved DNA repair, enhanced mitochondrial biogenesis, restored epigenetic regulation, activated autophagy, and improved nutrient sensing

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Free Radical Biol Med 46:154162 [DOI] [PMC free article] [PubMed] [Google Scholar] Reed M, Meszaros K, Entes L, Claypool M, Pinkett J, Brignetti D, Luo J, Khandwala A, Reaven G (1999) Effects of maso-procol on carbohydrate and lipid metabolism in a rat modelof type II diabetes

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