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Here, we provide structural evidence for the ability of the glutaminase enzymes to form filaments upon substrate binding, and present the first cryo-EM structures of the human full-length glutaminase isozyme GLS2 that offer an unprecedented view of the mechanism responsible for catalyzing glutamine hydrolysis

The tested animals that were listed in the patent include rats, mice, rabbits, guinea pigs and pigs, as well as a single study in humans

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