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We also wrote about antibodies & autoimmunity that can cause a B12 deficiency and B12 deficiency anemia

Moreover, certain medications, including metformin, proton pump inhibitors, and antacids may also reduce your bodys ability to absorb vitamin B12 from your diet (1, summary Vitamin B12 deficiency can manifest itself through a variety of symptoms

If your deficiency is due to temporary dietary factors that have been resolved, your provider might reduce the frequency or transition you to oral supplements

Li et al demonstrated that vitamin B12 may up-regulated insulin like growth factor-1 (IGF-1) gene expression, and showed a better neuroprotective effect in the presence of good control of hyperglycemia in rats with diabetic peripheral neuropathy 20