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Research shows that nigral dopamine neurons are particularly sensitive to glutathione depletion , explaining why Parkinson's disease targets this region so severely [5]

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348.Hernndez-Lahoz C, Rodrigo L

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The overexpression or overactivity of kynurenine 3-monooxygenase (KMO), the enzyme that converts KYN into KYNA due to single nucleotide polymorphisms, has been hypothesized, but the evidence remains insufficient [116]

Among them, folic acid, or its active form, L-methylfolate, shows promise due to folates association with an elevated risk of depression, severe depressive symptoms, prolonged duration of depressive episodes, and increased likelihood of relapse [22,23]