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Ethics declarations Ethics approval and consent to participate The whole protocol was approved by the Research Ethics Committee of Mashhad University of Medical Sciences (registration code: IR.MUMS.fm.REC.1396.671), and written informed consent was obtained from all of the patients or their families directly

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Luo C, Lancaster MA, Castanon R, Nery JR, Knoblich JA, Ecker JR (2016) Cerebral organoids recapitulate epigenomic signatures of the human fetal brain Malhotra AK, Pinals DA, Adler CM, Elman I, Clifton A, Pickar D, Breier A (1997) Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics Malhotra D, Sebat J (2012) CNVs: Harbingers of a rare variant revolution in psychiatric genetics

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