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Intriguingly, when older mice were given MOTS-c injections to restore their MOTS-c to more youthful levels, it reversed certain aging effects specifically, it restored insulin sensitivity in aged muscles and improved the animals exercise capacity to levels comparable with younger mice

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To directly investigate the effects of vitamin E supplementation on insulin sensitivity in hypertension, in relation to the effects on circulating levels of reduced (GSH) and oxidized (GSSG) glutathione and on Mg[i], we performed a 4-week, double-blind, randomized study of vitamin E administration (600 mg/d) versus placebo in 24 hypertensive patients and measured whole-body glucose disposal (WBGD) by euglycemic glucose clamp, GSH/GSSG ratios, and Mg[i] before and after intervention