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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Flanagan J.U., Smythe M.L

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Originally identified by Loren Pickart in human plasma, GHK-Cu has been the subject of extensive cellular biology and biochemical research literature for over five decades, with research contexts examining tissue biology, cellular signaling pathways, copper-binding peptide chemistry, and extracellular matrix research

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however, it is important to realise that betacyanins are unlikely to be exclusively eliminated via the renal pathway [36] Indeed, the use of urinary excretion as a sole indicator of bioavailability has received criticism because it does not account for the biliary and circulatory clearance of compounds, thus underestimating true bioavailability [33]

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