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10.1038/s41563-024-01933-w Nat Mater

Fibrosis may also be stimulated by upregulating the MDA/4-HNE pathway

The formulation of IGF-1 used in this study (IGF-1/BP3) is already bound to its endogenous-binding protein (BP3) and, as a result, has a greater specificity of action and significantly less hypoglycemic effect

Microglia are initially activated to stage 1 DAM, which are characterized by a downregulation of homeostatic microglial genes including p2ry12 and cx3cr1 , and an upregulation of genes including trem2 , tyrobp and apoe

Kraft et al., 2004)