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Description
& Weller, P

In addition to oncogenic regulators, there are some key upstream regulators of glutamine metabolism that are widely recognized for their pivotal role during tumorigenesis

p62 acts as a bridge between ubiquitinated proteins and the autophagic machinery, facilitating the degradation of ubiquitinated substrates via autophagy

I dont know the answer to that really
The role of oxidative damage and stress in aging

doi: 10.1007/s11095-011-0500-z
