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In diabetes, persistent hyperglycemia stimulates the production of reactive oxygen species from various sources

However, the addition of trisomy 21 in the first case, and raised adenosine in the second, brings the profiles much closer to those observed in patients with Down syndrome and autism, respectively

[DOI] [PMC free article] [PubMed] [Google Scholar] 400.Choi S.-K., Nishida Y., Matsuda S., Adachi K., Kasai H., Peng X., Komemushi S., Miki W., Misawa N

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Peroxidation byproducts can also exacerbate ROS production and bind to DNA and proteins, damaging them