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In the Tyr-Cre mouse, Cre is fused to the oestrogen receptor, therefore only when treated with tamoxifen, will Cre result in BrafV600E activation and Pten loss

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781 Additionally, hepatocytes near the injury site upregulate Wnt/-catenin target genes and pericentral metabolic enzymes regulated by Wnt/-catenin, consistent with the regenerative effects promoted by Wnt2 and Wnt9b in pericentral endothelial cells

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What monitoring protocol do you use for patients on this therapy

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doi: 10.1038/nature21363 365 CahillGFJr

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The intestinal mucosa contains a variety of immune cells in addition to enterocytes with absorptive functions

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