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Timing of onset of adverse events with setmelanotide, an MC4R agonist, in patients with severe obesity due to LEPR or POMC deficiency
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2019) Mouse cardiac fibroblasts treated with TMAO also exhibited increased NLRP3 inflammasome activation, while silencing RNA (siRNA)-mediated knockdown of NLRP3 in cardiac fibroblasts blunted TMAO-induced cell proliferation as well as TGF- and collagen expression
