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For the ME green module, 25 genes were selected as key hub genes

In mitochondria, serine oxidation produces formate, which is transported to the cytosol

In its resting state, AhR forms a complex with heat shock protein 90 (HSP90), X-associated protein 2 (XAP2), and p23, localized in the cytoplasm

34 LisewskiA

Currently, the impact of environmental stress has attracted considerable interest, based on epidemiological findings

Age-related reduction of mitochondrial function is accompanied by a decline in the mitochondrial capacity for ATP production by oxidative phosphorylation [62], a reduction in the NAD + pool [63] by consuming processes (PARP, CD38, and SIRT1) [64], and further an increase in ROS generation by an inefficient electron transport chain (ETC) [26]