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10.1098/rsta.2015.0376 122 WangY.HouX.-W.LiangG.PanC.-W

Glutathione Glutathione is a ubiquitous thiol-containing isotripeptide (-glu-cys-gly, FW 307.3), consisting of glycine, glutamic acid and cysteine molecules which was first discovered by Sir Fredrick Gowland Hopkins in 1920s, synthesized de novo in mammalian cells (Figure 1)

and Burks et al

doi:10.2147/CIA.S361519

(58) performed single-nucleus RNA sequencing (snRNA-seq) on DCM, HCM, and non-failing heart samples, which led to the identification of transcriptional alterations and cellular sub-population changes in disease states, particularly fibroblast activation characteristics, which expanded the current understanding of pathomechanisms