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The hydrogen peroxide (H 2 O 2 ) content was determined as the method proposed by Patterson et al

Studies have shown how the treatment with polyphenols could promote apoptotic cell death in preneoplastic or neoplastic cells through a variety of mechanisms, including the modulation of cell cycle signaling, antioxidant enzyme activity and arrest of the cell cycle, among others, mitigating the development of tumors

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The IGF-1 (Insulin-like Growth Factor 1) pathway is a signaling cascade including the IGF-1R receptor, PI3K kinase, Akt kinase and downstream effectors