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Description

This IL-10-mediated suppression is driven by activation of the STAT3 signaling pathway in cancer cells: IL-10 binds to its receptor (IL-10R) on cancer cell membranes, triggering STAT3 phosphorylation and nuclear translocation

Nrf2, an inhibitor of NF-B, has a cerebrovascular protective effect to maintain the functional integrity of the blood-brain barrier and prevent the occurrence of neuroinflammation and degenerative CNS disorders (Li et al

RSL3 directly inactivates GPX4, lipid peroxidation, and results in ferroptosis [27]

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