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Most are claimed as inhibitors, but later it is discovered that they generate a neomorphic surface on E3 ligase thus inducing proximity between the E3 ligase and a neo-substrate, leading to the degradation of the latter 205

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In fact, we detect Tpx1.SO 2 H formation after mild 100 M H 2 O 2 stress in ctt1 cells (Additional file 6: Figure S6c), what suggests that intracellular levels of peroxides are higher than in a wild-type background

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