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Hyperhomocysteinemia is an independent risk factor of atherosclerosis in patients with metabolic syndrome

However, it is not recommended for use in newborns or premature infants, as neonates lack the metabolic capacity to process benzyl alcohol safely a contraindication explicitly noted in FDA guidance on benzyl alcohol toxicity in neonates

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Some healthcare professionals have hypothesised that immune system changes following correction of severe B12 deficiency might temporarily influence pre-existing inflammatory conditions, though this remains largely theoretical and lacks robust evidence in clinical literature