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These are usually bound to proteins with characteristic acyl-CoA binding domains and depending upon on the energy status of the cell, they are directed to particular metabolic pathways such as storage or energy production by many different proteins including fatty acid binding proteins and sterol carrier protein 2

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One study reported that plasma TMAO levels increased within 15 minutes of consuming fish, which suggests that dietary TMAO is absorbed without processing by gut microbes [9]

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