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Similar findings were observed with sestrin2 downregulation (Qian et al., 2023)

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In vitro assays were conducted at 37 C in a 50 L total volume

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Saudi Pharm J 23:107114

In addition, transgenic mice with cardiac-specific heat shock protein 27 (Hsp27) overexpression developed cardiac hypertrophy and dysfunction, which correlated with increases in GSH levels, GSH/GSSG, and GPx1 activity and with a decrease in total ROS levels in the heart (119)