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Ph-IOP is a key glaucoma characteristic and a major factor leading to RGC loss in patients with glaucoma (313)

To discover small molecules that reduce aggregate formation, an OASIS knock-in line, combined with high-content imaging, supported a 1280-compound screen that yielded 19 primary hits, of which, 5 showed neuroprotective activity

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Based on the analysis of all the results, we propose that lipid mobilization, lipid metabolism, and amino acid metabolism jointly participated in the synthesis of sterol hormones and ultimately promoted the vitellogenesis and ovarian development in the shrimp (Figure 12)