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It's common for people to be B12 deficient, especially in those who choose to eat a plant-based diet

Biased agonism at DOR and desensitization Evidence for a different DOR regulation by methadone and morphine was also reported

The half-life of 159 to 195 hours means there is some flexibility, a day early or late will not ruin the protocol, but regular weekly timing produces the most stable plasma levels
Tsolis P, Lahanas KM
