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The use of potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is, therefore contraindicated (see WARNINGS: CYP 3A4 Inhibitors)
It also creates practical questions for individual patients: is this investment worth it relative to other health priorities
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only upon failure of nondrug interventions should these medications be considered
Their integration into modern medical practices could give rise to innovative, comprehensive strategies against PF
