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Together these are called dual incretin signaling

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ER oxidative stress increases intracellular free radical generation, triggering inflammation and autoimmune responses ( Inflammatory response: ER oxidative stress induces the release of inflammatory factors like tumor necrosis factor- (TNF-), interleukin-6 (IL-6), which contribute to inflammation, edema, and fibrosis in ocular tissues associated with TAO (56)

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Translocator protein (18kDa) (TSPO)/peripheral benzodiazepine receptor (PBR) specific ligands induce microglia functions consistent with an activated state