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If not balanced by the functional antioxidant systems, an excessive increase in ROS levels leads to oxidative stress that causes structural and functional damage to the various biomolecules (lipids, proteins, and DNA), altering biological processes [15]

Therefore, both T2DM and PD show strong connections between mitochondrial damage and increased oxidative stress, resulting in altered insulin secretion in the former case, and in neuronal damage and neuroinflammation in the latter

Similar to phosphorylation, ubiquitination is reversible, and 85 deubiquitinases (DUBs) are known

Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses
