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Research has investigated its role in sleep-wake cycle regulation, pituitary hormone secretion, stress adaptation, and nociceptive pathways

doi: 10.1016/j.febslet.2010.04.050

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In addition, Nox4, along with Nox1, Nox2, is also expressed in vascular smooth muscle cells (VSMCs) (Huetsch et al., 2019)