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The mechanism appears to be interference with erythropoiesis

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The most significant reaction of mevalonate pathway, which represents the rate-limiting reaction, is catalyzed by 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR

BER enzymes are primarily targeted at removing N7-MeG and N3-MeA lesions, subsequently repairing the DNA through the collaborative action of DNA polymerase and DNA ligase, thus restoring the DNA strand to its original, non-damaged state [165]

Careful consideration and monitoring are necessary when combining folic acid with these medications to ensure optimal treatment outcomes

Hippocampal neurons were then cultured a further 3-7 days, at which time they were either transfected or treated with various pharmacological reagents as described in the text or figure legends