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The onset of MPT is characterized by the permeabilization of the MOM secondary to a sudden increase in permeability of the MIM, which allows the exit of molecules less than 1500 Da (Karch et al., 2013)

These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects

Schlosser, M

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CRediT authorship contribution statement Sulaiman Mohammad Alnasser: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review & editing