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Individuals diagnosed with OSA, especially those with moderate to severe manifestations of the condition who do not receive therapeutic intervention, demonstrate a markedly increased vulnerability to a spectrum of detrimental clinical sequelae

This pattern has also been observed in the development of other EBV-associated autoimmune diseases, such as lupus erythematosus (223)

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Decreased levels of both the GCLC and GCLM regulatory subunits of -GCL have been reported in the brains of aged mice, in the absence of changes in GS activity [57]

doi: 10.1016/j.hermed.2022.100572 78

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