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In fact, studies show that B12 deficiency is one of the leading nutrient deficiencies in the world, and is also a major health concern in many parts of the world, including the US, Mexico, Central and South America

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Persistent cellular damage provokes an inflammatory response that recruits innate immune cells (particularly macrophages) to the site of injury and elicits the release of pro-fibrotic factors, such as transforming growth factor (TGF-) and -smooth muscle actin (-SMA) [13]

Furthermore, the motor cortex of ALS patients contains epigenetic hypomethylation of the APE1 promoter (Kim et al., 2020)

doi: 10.3389/fphar.2023.1330098 Received 30 October 2023 Accepted 15 December 2023 Published 04 January 2024 Volume 14 - 2023 Edited by Andleeb Khan, Integral University, India Reviewed by Md
