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In individuals with MDD, mitochondrial abnormalitiessuch as structural degradation, disrupted mitochondrial DNA (mtDNA), and impaired electron transport chain (ETC) functionlead to excessive production of ROS, destabilizing neurotransmitter systems and exacerbating depressive symptoms [103,128,129,130]

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Thus, it can be that the general NO-system significance goes against the mentioned specific NO-agent drawbacks and against the current lack of suited NO-related therapy to specify and resolve given etiopathology [124,125]

Moreover, 5-FU treatment decreased the viability of the GST 4QN -p53-expressing cells compared to the GST WT -p53-expressing cells (Fig