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Transcriptomic analysis of iSPNs at the pre-symptomatic stage showed de-regulation of metabolic pathways, including upregulation of Gsto2, encoding glutathione S-transferase omega-2 (GSTO2)

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Vomiting becomes more common at this stage, particularly if large meals, rich foods, or alcohol are consumed

[DOI] [PubMed] [Google Scholar] Ritter C.A., Sperker B., Grube M., Dressel D., Kunert-Keil C., Kroemer H.K

Ethics declarations Competing interests M.C.J

Autophagy 6, 138143